Chris Hemsworth is well-known for his role in Marvel Cinematic Universe films as Thor. He has now announced that he will be retiring. Take a breakHe was told that he has two copies. APOE4 geneHis risk of being arrested for a crime increases. Alzheimer’s.
One copy of the APOE4 geneYour risk of developing Alzheimer’s disease 2-3 times increases Your risk of developing Alzheimer’s disease is increased by two copies, which increases your chances by 10-15%.
The key word here is “risk”. Having one or two copies of the gene does not guarantee that Chris, or anyone else in a similar position, will develop Alzheimer’s.
Sharing the news
We should applaud Hemsworth for sharing his concerns about Alzheimer’s disease with millions. It is a reminder for all of us that we need to be vigilant about our health and minimize our chance of developing future illnesses.
Alzheimer’s disease, and dementia in general, are Take on the challengeHealthcare systems around the world
There are a total of 68 in Australia. Up toNearly 1.6 Million caregivers are supporting 500,000 dementia sufferers. By 2036, about 450Daily diagnosis is expected.
Understanding how APOE4 affects the risk of the main cause of dementia could be crucial in preventing these cases.
However, not all people who have the APOE4 gene develop Alzheimer’s. This may indicate that some people will develop Alzheimer’s because of a combination or interplay between environmental factors and the gene.
What has APOE4 to do about Alzheimer’s disease?
Most Australians possess APOE3 or APOE2 gene. Caucasians have it only. Around 15%Hemsworth is one of many people who have inherited the APOE4 gene.
The APOE gene type is best known for its role in modulating metabolism of lipids (fats), like cholesterol and triglycerides.
They allow for the synthesis and modification of different versions of APOE protein with subtle differences of structure. The APOE protein becomes an integral part blood lipoproteins. These are the fat-carrying particles that your GP considers when assessing your risk for heart disease.
The brain’s function for APOE proteins is to regulate lipid levels. However, in Alzheimer’s disease context, scientists study it to see if it affects the integrity of brain cells.
Accumulating evidence It is possible to suggestAPOE4, which is associated with brain inflammation, cellular damage and cell death, is known as APOE4.
Can we prevent Alzheimer’s?
1. Take care of your capillaries
Inflammation, death of brain cells and cognitive impairment can be caused by damaged or leaky blood vessels (capillaries). Damaged capillaries in Alzheimer’s disease are the first sign of the type brain damage that can cause it.
The APOE4 protein may not be able to support healthy blood vessels in the brain. We recommendedAPOE4 increases blood levels of certain lipoproteins and protein complexes that silently harm brain capillaries. This causes them to leak.
Also, brain capillary leakage is more prevalent in mice that are fed Western-style diets higher in saturated fats.
It is not clear how the APOE proteins influence lipid metabolism and capillary health in human beings.
We have 60 years worth of research to prove that good foods for the heart are good for your brain. This is especially relevant to people who have the APOE4 genes.
A healthy diet is a good place for anyone with the APOE4 gene.
2. Give your brain a break
Your life will be impacted for many decades if you can reduce unnecessary stimuli. This is especially important if you have APOE4 genes.
This is because the APOE gene may also be linked to energy use by the brain, which could lead to even more Oxidative stress and other damage.
We haven’t yet collected any solid data on humans. Take a digital detox, schedule some downtime, avoid unnecessary stress, and take regular breaks.
Do we need to test for the APOE4 genetic gene?
People might feel tempted to test for the APOE4 gene, particularly if they have a family history with Alzheimer’s.
However, genetic testing is not recommended if it is going to alter your treatment (for example, taking certain medications to slow the progression of brain damage) or your behavior to reduce your risk of developing Alzheimer’s.
While we cannot change the genes that our parents gave us, we can alter our environment.
Poor diet, every drop you drink of alcohol, obesity. DiabetesHigh blood pressure and sedentary behaviour all contribute, over timeThis can lead to poorer vascular health, and an increase in your risk of developing dementia.
It’s still unclear how these risk factors for Alzheimers relate to the APOE4 genetic. We don’t have to all assume greater responsibility for minimizing our dementia risk, regardless of whether or not we have the APOE4 genes.
John MamoJohn Curtin Distinguished Chair in Health Sciences, Curtin Health Innovation Research Institute Director Curtin University
This article has been republished from The ConversationUnder a Creative Commons License Please read the Original article.
